Thomas R. Howdieshell

Contact


Phone: 505-272-6441

Photo: true

Professor

Department of Surgery

Education

Trauma/Burns/Surgical Critical Care Fellowship, University of New Mexico, Albuquerque, NM, 1987-1988

General Surgery Residency, Medical College of Georgia, Augusta, GA, 1987

Medical College of Georgia (Alpha Omega Alpha), 1982

Biography

Thomas R. Howdieshell, M.D. is a Professor of Surgery and a Professor of Cell Biology and Physiology at the University of New Mexico. He received his M.D. in 1982 from the Medical College of Georgia, completed a residency in General Surgery from the same institution in 1987 and was a fellow in Trauma and Burn Surgery at the University of New Mexico from 1987 to 1988. His current research involves investigation of laser scatter contrast imaging, a noninvasive method of mapping surface blood flow, as a method to predict the temporal and spatial pattern of ischemia and return of functional revascularization, with corroboration by simultaneous histopathological analysis and quantitative determination of microvascular density by CD-­‐31 immunostaining. Using PCR-­‐based gene arrays, he is examining the expression of a panel of chemokine and growth factor genes known to play roles in the angiogenic process as well as factors known to stimulate the recruitment of hematopoietic stem cells. This analysis will allow the identification of specific molecular biomarkers associated with measurements of functional cutaneous blood flow during normal and impaired healing. Identification of a transcriptional profile associated with a nonhealing diabetic wound may determine specific genes that prevent a wound from healing, and could be utilized to develop therapies to prevent wound chronicity and promote wound healing. He is also currently investigating the recruitment of monocyte subsets in wound angiogenesis, and collaborates with other Center for Biomedical Engineering researchers in development of tissue scaffolds for monocyte and endothelial infiltration. Finally, he is interested in endothelial barrier dysfunction in relation to trauma-­‐induced capillary leak syndrome and has begun utilizing cell culture methods (ECIS and TER) to evaluate mediators involved in endothelial dysfunction.

Research Interests

  • Clinical practice in the areas of trauma surgery, surgical critical care, and burn surgery. Basic science research in the area of wound healing.